The Differential Impact of <i>APOE ε4</i> on Normative Cognitive Aging in Research Samples from the United States and Korea
Results show variability in normative cognitive aging patterns between research study participants in United States and Korean imaging studies. APOE ε4 was more influential in rates of decline among Korean participants. These findings underscore the importance of replicating findings, diversifying study populations, and of considering ethnic and racialized backgrounds when examining genetic risk and cognitive aging, as different populations may show distinct patterns of decline.
Authors
- Adam M. Staffaroni (ORCID: https://orcid.org/0000-0002-3903-9805)
- Kacie Deters
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Jeremy A. Tanner (ORCID: https://orcid.org/0000-0001-9828-1776)
- Diefei Chen (ORCID: https://orcid.org/0000-0002-9195-3311)
- Andrew Joel Saykin
- Joshua Garcia
- Kwangsik Nho
- Dahyun Yi
- Martine Elbejjani
- C. Elizabeth Shaaban
- A. Zarina Kraal
- Luis D. Medina
- Dong Young Lee
- Paul K Crane
- Shannon L Risacher
Institutions
- Seoul National University (KR)
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- University of Washington (US)
- Seoul National University Hospital (KR)
- University Memory and Aging Center (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Institute for Neurodegenerative Disorders (US)
- Institute on Aging (US)
- Indiana University School of Medicine
- University of Houston (US)
- Indiana University – Purdue University Indianapolis (US)
- American University of Beirut (LB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_107664
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00