Characterisation of plasma phosphorylated Tau181 in a middle‐aged birth cohort: Associations with cognitive decline, brain structural integrity, and accelerated ageing
The range of pTau181 levels observed suggests that blood biomarkers of AD may increase early in middle age, decades prior to any potential disease onset and possibly before any measurable cognitive decline or neurostructural abnormalities. Future assessment waves in the same cohort will elucidate whether plasma pTau181 in midlife is predictive of AD onset later in life.
Authors
- Sean Hogan (ORCID: https://orcid.org/0000-0001-8568-3426)
- Tracy R. Melzer (ORCID: https://orcid.org/0000-0003-0621-212X)
- Richie Poulton (ORCID: https://orcid.org/0000-0002-1052-4583)
- Sandhya Ramrakha (ORCID: https://orcid.org/0000-0002-0383-9886)
- Elizabeth Goodin (ORCID: https://orcid.org/0000-0002-5082-8231)
- Renate Houts (ORCID: https://orcid.org/0000-0002-1518-2631)
- Erin E. Cawston (ORCID: https://orcid.org/0000-0003-2560-1630)
- Jesse Kokaua (ORCID: https://orcid.org/0000-0001-8740-1277)
- David Ireland (ORCID: https://orcid.org/0000-0001-7343-916X)
- Tim Anderson
- Reremoana F. Theodore (ORCID: https://orcid.org/0000-0002-1057-9859)
- Annchen R. Knodt (ORCID: https://orcid.org/0000-0001-6501-8947)
- Antony Ambler (ORCID: https://orcid.org/0000-0002-7553-3632)
- Wickliffe C. Abraham (ORCID: https://orcid.org/0000-0001-9919-0622)
- Karen Sugden (ORCID: https://orcid.org/0000-0002-4076-5927)
- P.D. Wilson
- Kirsten Cheyne (ORCID: https://orcid.org/0000-0003-1475-3639)
- Avshalom Caspi
- Ben Williams
- Ahmad R. Hariri
- Terrie E. Moffitt
- Brigid Ryan
- Ashleigh Barrett‐Young
Institutions
- University of Auckland (NZ)
- Duke University (US)
- King's College London (GB)
- University of Canterbury (NZ)
- New Zealand Brain Research Institute (NZ)
- Brain Research New Zealand (NZ)
- University of Otago (NZ)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099207
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00