Tau PET positivity rates in relation to meningeal off‐target signal MK6240, PI2620, and flortaucipir scans
Elevated OTS was observed in the T+Ab- group in PI2620 across all OTS ROIs. Since CU Ab- subjects are not expected to have above-threshold tau burden, OTS may be spilling into target regions resulting in false positives. Next steps include visual inspection of T+Ab- scans to determine OTS-related false tau positivity rate.
Authors
- Karly Alex Cody (ORCID: https://orcid.org/0000-0001-5996-2560)
- Suzanne L. Baker (ORCID: https://orcid.org/0000-0003-0209-3127)
- Elizabeth C. Mormino (ORCID: https://orcid.org/0000-0002-4542-6537)
- Theresa M. Harrison (ORCID: https://orcid.org/0000-0002-2036-3496)
- Trevor Chadwick
- Yishu Chao
- William J. Jagust
- Susan M. Landau
Institutions
- Lawrence Berkeley National Laboratory (US)
- University of California, Berkeley (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100456
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00