Brain telomere length associates with hippocampal ptau and is mediated by DNA methylation
In a PART cohort, shorter frontal cortex brain-TL was related to higher hippocampal ptau, and this relationship was partially mediated by a DNA methylation model predictive of hippocampal ptau. A polygenic score for LTL was not predictive of brain-TL or hippocampal ptau. Together, this further emphasizes the importance of tissue-specific epigenetic modifiers of age-related ptau neuropathology.
Authors
- Anil R. Wadhwani (ORCID: https://orcid.org/0000-0002-7007-2371)
- Wanding Zhou (ORCID: https://orcid.org/0000-0001-9126-1932)
- Kurt W. Farrell (ORCID: https://orcid.org/0000-0001-6955-7278)
- Corey T. McMillan (ORCID: https://orcid.org/0000-0002-7581-6405)
- Lasya P Sreepada (ORCID: https://orcid.org/0000-0001-8000-7074)
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Q. Chen
- John F. Crary (ORCID: https://orcid.org/0000-0002-0556-293X)
- Isabella Leone
- Nadia Dehghani (ORCID: https://orcid.org/0000-0002-0385-7267)
- Part Working Group
- Jin Jin
- Eddie B. Lee
- F. Bradley Johnson
- David C. Goldberg
- Angelina Jala
Institutions
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105996
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00