White matter integrity predicts executive dysfunction in later‐life attention deficit/hyperactivity disorder
Impaired WMI in diffuse tracts that support executive function in ADHD may contribute to increased risk for cognitive decline and dementias that present with primary executive dysfunction. Future research should examine neurobiological and lifestyle factors that may interact with decreased WMI in ADHD to augment dementia vulnerability. Identification of deficient WMI as a unique contributor to poor cognitive aging in ADHD may lead to targeted preventative interventions for this neurodiverse, high-risk group.
Authors
- Andrew E. Beaudin (ORCID: https://orcid.org/0000-0002-3295-7232)
- Jodie R. Gawryluk (ORCID: https://orcid.org/0000-0003-4924-7517)
- Natalia Docteur (ORCID: https://orcid.org/0000-0001-5937-8444)
- Eric Edward Smith (ORCID: https://orcid.org/0000-0003-3956-1668)
- Sara Becker
- Brandy L. Callahan (ORCID: https://orcid.org/0000-0001-5617-2379)
- Ryan T. Muir (ORCID: https://orcid.org/0000-0002-9349-1069)
- Hayley G.P. Huston (ORCID: https://orcid.org/0009-0007-6345-1780)
- Lanea Jackson
- S. Benjamin Peckham
Institutions
- University of Calgary (CA)
- University of Victoria (CA)
- Ontario Brain Institute (CA)
- Hotchkiss Brain Institute (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_104000
- Primary Topic
- Attention Deficit Hyperactivity Disorder
- Type
- article
- Field-Weighted Citation Impact
- 0.00