Insulin Resistance in Human Hippocampal Pyramidal Neurons Correlates with Age in Cognitively Normal and Alzheimer's Disease Patients
These results suggest that brain insulin resistance increases with age, before peaking in ADd and decreasing as neurodegeneration proliferates. The correlations between IRS-1<sup>pS616</sup>, β-amyloid, and phospho-tau pathologies also suggest that accumulation of cytoplasmic IRS-1<sup>pS616</sup> in pyramidal neurons is involved in ADd pathogenesis. Further study may provide evidence towards a mechanism of action for insulin resistance therapies in AD with IRS-1<sup>pS616</sup> as a biomarker of brain insulin resistance.
Authors
- Konrad Talbot (ORCID: https://orcid.org/0000-0003-4549-0835)
- Tim Distel
- Xuelin Gu
Institutions
- Loma Linda University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106242
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00