Evaluation of Alzheimer's disease biomarkers and cognition in non‐Hispanic Black and non‐Hispanic White participants in ADNI and US POINTER Imaging
NHBs had lower Aβ and EC tau than NHWs in POINTER but not ADNI, and there were inconsistent associations between Aβ and EC tau across cohorts. Despite these differences, AD biomarkers appear similarly related to cognitive outcomes across ethnoracial groups in both cohorts. Future analyses will attempt to further determine the generalizability of AD biomarker relationships in diverse samples by considering matching on relevant health and demographic characteristics, and inclusion of additional cohorts with harmonized biomarker and cognitive measurements.
Authors
- Heather M. Snyder (ORCID: https://orcid.org/0000-0002-7665-7696)
- Laura D. Baker (ORCID: https://orcid.org/0000-0002-6217-7384)
- Talia L. Robinson (ORCID: https://orcid.org/0000-0002-5655-8324)
- Theresa M. Harrison (ORCID: https://orcid.org/0000-0002-2036-3496)
- Rebecca England Amariglio (ORCID: https://orcid.org/0009-0009-5878-8930)
- Susan M. Landau
- Alzheimer's Disease Neuroimaging Initiative US POINTER Study Group
- Charles S. DeCarli
- Kathryn V Papp
- Prashanthi Vemuri
Institutions
- Alzheimer's Association (US)
- Brigham and Women's Hospital (US)
- Massachusetts General Hospital (US)
- Mayo Clinic in Arizona (US)
- Wake Forest University (US)
- University of California, Davis (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100136
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00