Feasibility of Identifying Aerobic‐Fitness Responses to Aerobic Exercise in Alzheimer's Disease: The FIT‐AD SMART Trial
The findings indicate that VO2peak did not improve among half of participants assigned to MICT following 3-months of training, although the amount of improvement was considerable among responders. These findings underscore the importance of using VO2peak as a key physiological marker for identifying exercise non-response in older adults with AD early during exercise interventions. Subsequent tailoring of exercise interventions following non-response to MICT may help maximize the benefits of aerobic exercise on cognitive health.
Authors
- Rodney P. Joseph (ORCID: https://orcid.org/0000-0001-5162-7637)
- Michael Todd
- Jeremy J. Pruzin (ORCID: https://orcid.org/0000-0002-0443-4194)
- David W. Coon (ORCID: https://orcid.org/0000-0002-5224-3886)
- Fang Yu (ORCID: https://orcid.org/0000-0002-7495-6449)
- Molly Maxfield (ORCID: https://orcid.org/0000-0002-3502-2176)
- Danni Li
- Yi Su
Institutions
- University of Minnesota (US)
- Banner Alzheimer’s Institute
- Arizona State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70858_098678
- Primary Topic
- Cardiovascular and exercise physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00