Mitochondrial blood‐based biomarker is related to fitness and aging in a sex‐dependent manner
We combined a MHI with measures related to physical fitness in a cognitively healthy older adult population. We explored physiological factors that impact fitness and response to exercise training, such as sex. We observed relationships between mitochondrial measures and OUES and lean mass in females, whereas males had higher MHI overall. Sex-depended differences in mitochondrial health and ROS likely contribute to the variable response to exercise training between males and females, and might help explain differences in AD risk between sex.
Authors
- Paul J. Kueck (ORCID: https://orcid.org/0000-0002-9102-2058)
- Jill K. Morris (ORCID: https://orcid.org/0000-0001-5911-4190)
- Amanda N. Szabo‐Reed (ORCID: https://orcid.org/0000-0002-4927-1501)
- Riley E. Kemna
- Eric Dennis Vidoni
- Casey S. John
- Hana D. Mayfield
- Jenae Pennington
Institutions
- University of Kansas (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- University of Kansas Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106196
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00