NETSseq unveils deep molecular insights into astrocyte function in Alzheimer's disease in the human brain
Along with generating highly reproducible molecular profiles from specific CNS cell types, NETSseq enables the understanding of temporal dynamics of chromatin and gene expression changes across disease progression, thereby identifying relevant pathways and genes to target as novel therapeutic strategies.
Authors
- Gonca Bayraktar (ORCID: https://orcid.org/0000-0001-5476-4346)
- Nicola Brice (ORCID: https://orcid.org/0000-0003-4533-9369)
- David Cadwalladr
- Marina Lizio (ORCID: https://orcid.org/0000-0001-7337-7325)
- Jason Lawrence
- Craig B. Thompson (ORCID: https://orcid.org/0000-0003-3580-2751)
- Keith J. Page (ORCID: https://orcid.org/0000-0003-0717-396X)
- Mark Carlton
- Toni Cheung
- Justin Powell
- Lee A. Dawson
- Dino Ossola
- Chris Ugbode
- Xiao Xu
- Daniel Barker
Institutions
- Cambridge Environmental Research Consultants (United Kingdom) (GB)
- European Organization for Nuclear Research (CH)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106433
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00