Clinical, Cognitive, and MRI Profiles in a Memory Clinic Cohort with Negative Versus Positive PET Amyloid Scans

This descriptive study suggests that amyloid-negative patients are more likely to present with aMCI than dementia, and exhibit milder memory deficits than amyloid-positive patients, aligning with reports that LATE may be less severe than AD. Though referral bias may partly explain the higher proportion of aMCI in the amyloid-negative group, these findings underscore the need to consider non-AD pathologies in patients with memory complaints and negative amyloid scans. Future research may elucidate distinct clinical signatures to improve diagnostic workflows in memory clinics.