The effect of oxysterol imbalance in synaptic dysfunction

Our study highlights the detrimental effects of 27-OHC on neuronal and astrocytic function, identifying key molecular targets involved in synaptic integrity and glutamate homeostasis. The observed dysregulation of SNAP25, PSD95, REST/PTBP1, and astrocytic RAGE, GLT-1, and GLAST underscores the role of oxysterol-induced neurotoxicity in neurodegenerative processes. Targeting these pathways may offer novel therapeutic strategies for conditions characterized by cholesterol dyshomeostasis and excitotoxicity.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_105023
Primary Topic
Cholesterol and Lipid Metabolism
Type
article
Field-Weighted Citation Impact
0.00
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article

The effect of oxysterol imbalance in synaptic dysfunction

Raúl Loera‐Valencia
Alzheimer s & Dementia
Cholesterol and Lipid Metabolism
article

The effect of oxysterol imbalance in synaptic dysfunction

Raúl Loera‐Valencia
article en

Abstract

Our study highlights the detrimental effects of 27-OHC on neuronal and astrocytic function, identifying key molecular targets involved in synaptic integrity and glutamate homeostasis. The observed dysregulation of SNAP25, PSD95, REST/PTBP1, and astrocytic RAGE, GLT-1, and GLAST underscores the role of oxysterol-induced neurotoxicity in neurodegenerative processes. Targeting these pathways may offer novel therapeutic strategies for conditions characterized by cholesterol dyshomeostasis and excitotoxicity.

Alzheimer s & DementiaVol. 21(S1)
Tecnológico de Monterrey (MX)
Openalex Percentile: Top 26%
Cholesterol and Lipid Metabolism
DOIOpen Access PDFOpenAlex
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The effect of oxysterol imbalance in synaptic dysfunction — Raúl Loera‐Valencia · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS