Increased Metabolism in Corona Radiata as a Signature of Lower Cognitive Resilience in Aging and Alzheimer's Disease
We found unexpected metabolism increases in corona radiata, a hub that carries significant portion of the brain's neural traffic, with aging and disease which likely indicates a compensatory response. These changes may be useful cognitive resilience measures and require further investigation to understand their role in maintaining cognitive function.
Authors
- Val J. Lowe (ORCID: https://orcid.org/0000-0002-5612-1667)
- R. C. Petersen
- Jonathan Graff‐Radford
- Scott A. Przybelski (ORCID: https://orcid.org/0009-0009-3437-3773)
- Jianqiao Tian (ORCID: https://orcid.org/0000-0002-3994-2922)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-7800-3189)
- Heather J. Wiste (ORCID: https://orcid.org/0009-0002-8833-2693)
- Mary M. Machulda
- Robert Reid
- Sheelakumari Raghavan
- Christopher G Schwarz
- Matthew L. Senjem
- Clifford R. Jack
- Prashanthi Vemuri
Institutions
- Mayo Clinic (US)
- WinnMed (US)
- Nanjing Drum Tower Hospital (CN)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103799
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00