Examining the interaction of sex and APOE 4 status in predicting hallucinations relative to delusions in AD
Findings suggest that APOE4 homozygosity increases psychosis risk among males relative to heterozygotes and females relative to non-carriers, with effects being limited to hallucinations. Pooled analyses in both sexes showed effects of APOE4 mainly in delusions and auditory hallucinations. This data suggests the sex effects of APOE4 may be stronger for hallucinations relative to delusions though further studies in larger samples are needed to corroborate this finding. It should also be noted that these analyses did not adjust for LB pathology.
Authors
- Mila Valcic (ORCID: https://orcid.org/0000-0001-8125-5547)
- Neda Rashidi‐Ranjbar (ORCID: https://orcid.org/0000-0002-2125-1090)
- Simon Graham (ORCID: https://orcid.org/0000-0002-2214-8212)
- Nathan W. Churchill (ORCID: https://orcid.org/0000-0001-8481-2505)
- Marc A. Khoury (ORCID: https://orcid.org/0000-0001-5863-6974)
- DG Munoz
- Corinne E. Fischer
- Vincenzo De Luca
- Tom A. Schweizer
- Gayathiri Rajkumar
- Luis R Fornazzari
Institutions
- St. Michael's Hospital (CA)
- Sunnybrook Health Science Centre (CA)
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_099379
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00