The HMGB1/RAGE/β-catenin axis mediates aberrant osteogenic-tenogenic differentiation imbalance of tendon stem/progenitor cells in diabetic tendinopathy
Our findings revealed the critical role of the HMGB1/RAGE/β-catenin axis in the differentiation imbalance of TSPCs and diabetic tendinopathy, highlighting a novel essential mechanism involved in the pathogenesis of diabetic tendinopathy and providing a promising therapeutic target and approach for diabetic tendinopathy.
Authors
- Hao Wang (ORCID: https://orcid.org/0000-0003-1040-3009)
- Yunfeng Rui
- Liu Shi
- Yingjuan Li
- Panpan Lu
- Yucheng Gao (ORCID: https://orcid.org/0000-0002-0337-9285)
Institutions
- Zhongda Hospital Southeast University (CN)
- Southeast University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1186/s13018-025-06572-8
- Primary Topic
- Tendon Structure and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00