Transcriptomic Analysis of the effects of DDT, and its metabolite, DDE, on Alzheimer's pathology in 5xFAD mice
Overall, these findings demonstrate that exposure of 5xFAD mice to DDT and DDE differentially affect AD-related pathways and neurodegeneration. Importantly, they provide mechanistic evidence of DDE's neurotoxicity, reinforcing epidemiological findings and challenging the assumption that DDE is biologically inert in the brain.
Authors
- Isha Mhatre‐Winters (ORCID: https://orcid.org/0000-0003-3498-8355)
- Arturo Barahona (ORCID: https://orcid.org/0000-0001-5982-9516)
- Ferass M. Sammoura
- Jason R Richardson
- Yoonhee Han
Institutions
- University of Georgia (US)
- Florida International University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106994
- Primary Topic
- Toxic Organic Pollutants Impact
- Type
- article
- Field-Weighted Citation Impact
- 0.00