Cognitive reserve as a moderator of the association between hippocampal volume and entorhinal thickness and later‐life behavioral symptoms

Findings indicate that greater CR mitigates NPS associated with hippocampal atrophy, independent of cognition, suggesting that CR may provide protective benefits that extend beyond cognition. Future research should explore outcomes longitudinally, consider domain-specific analyses, and explore whether these findings extend to functional imaging surrogates of CR.