Genetic architecture of the limbic white matter microstructure in aging and Alzheimer's Disease
This study identified genetic factors related to cognition, vascular health, and inflammation as contributors to WM microstructure changes in aging and AD. These findings open avenues for future research on AD's molecular mechanisms and therapeutic targets for improving vascular and metabolic health in aging populations.
Authors
- Panpan Zhang (ORCID: https://orcid.org/0000-0002-2124-2733)
- Nancy R. Newlin (ORCID: https://orcid.org/0000-0003-3714-4684)
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Karthik Ramadass (ORCID: https://orcid.org/0000-0002-4610-3860)
- Niranjana Shashikumar
- Sarah Biber
- Derek B. Archer (ORCID: https://orcid.org/0000-0001-8638-0785)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Christos A. Davatzikos (ORCID: https://orcid.org/0000-0002-1025-8561)
- Lori L. Beason‐Held (ORCID: https://orcid.org/0000-0001-9057-6270)
- Praitayini Kanakaraj (ORCID: https://orcid.org/0000-0002-9979-217X)
- Konstantinos Arfanakis (ORCID: https://orcid.org/0000-0001-9705-597X)
- Michael E. Kim (ORCID: https://orcid.org/0009-0006-3562-2688)
- Tianyuan Yao (ORCID: https://orcid.org/0000-0002-1848-079X)
- Kimberly R. Pechman (ORCID: https://orcid.org/0000-0003-0596-8064)
- Duygu Tosun (ORCID: https://orcid.org/0000-0001-5174-3910)
- Elizabeth C. Mormino (ORCID: https://orcid.org/0000-0002-4542-6537)
- Alaina Durant
- Lisa Laverne Barnes
- Nazirah Mohd Khairi (ORCID: https://orcid.org/0000-0003-2180-3200)
- Andrew Joel Saykin
- Aditi Sathe
- Yuankai Z Huo
- Yisu Yang
- Anna Lorenz (ORCID: https://orcid.org/0009-0003-4344-7486)
- Marilyn S. S. Albert
- Walter W. Kukull
- Yiyang Wu
- Bennett A. Landman
- Alzheimer's Disease Neuroimaging Initiative (ADNI), The BIOCARD Study Team, The Alzheimer's Disease Sequencing Project (ADSP)
- Di Wang
- Guray Erus
- Julie A Schneider
- Kurt Schilling
- Angela L. Jefferson
- Sterling C Johnson
- Susan M. Resnick
- David A. A. Bennett
- Yang An
- Arthur W. Toga
- Shannon L Risacher
- Zhiyuan Li
- Mohamad Habes
- Chenyu Gao
- Barbara B. Bendlin
- Paul M. Thompson
Institutions
- University of Southern California (US)
- Rush University Medical Center (US)
- National Institutes of Health (US)
- University of Wisconsin–Madison (US)
- Johns Hopkins University (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of California, San Francisco (US)
- Vanderbilt University (US)
- University of Washington (US)
- Johns Hopkins Medicine (US)
- University of Wisconsin Health (US)
- National Institute on Aging (US)
- Wisconsin Division of Public Health (US)
- Artificial Intelligence in Medicine (Canada) (CA)
- Indiana University School of Medicine
- The University of Texas at San Antonio (US)
- Rush University (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
- The University of Texas Health Science Center at Houston (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098641
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00