Voxel‐wise longitudinal changes between amyloid PET and executive function subcomponents at the preclinical stage of the Alzheimer's continuum
Subtle cognitive decline across core EF subcomponents-attention, cognitive control, and working memory-was associated with distinct regional patterns of amyloid accumulation in CU individuals. These distinctive change-on-change signatures offer insights into the specific brain regions implicated in AD-related EF decline and underscore the importance of tailored neuropsychological assessments for monitoring subtle cognitive changes in preclinical AD.
Authors
- Gemma Salvadó (ORCID: https://orcid.org/0000-0002-5210-9230)
- Gwendlyn Kollmorgen
- Kaj Blennow
- Carolina Minguillón (ORCID: https://orcid.org/0000-0002-2782-6908)
- David López‐Martos (ORCID: https://orcid.org/0009-0008-1150-2619)
- for the ALFA study
- Gonzalo Sánchez‐Benavides
- Oriol Grau‐Rivera
- Marta Milà‐Alomà
- Henrik Zetterberg
- Marc Suárez‐Calvet
- Juan Domingo Gispert
- Mahnaz Shekari
Institutions
- University of Wisconsin–Madison (US)
- University of California, San Francisco (US)
- Lund University (SE)
- Sahlgrenska University Hospital (SE)
- Instituto de Salud Carlos III (ES)
- Roche Pharma AG (Germany) (DE)
- Pasqual Maragall Foundation (ES)
- UK Dementia Research Institute (GB)
- Barcelonaβeta Brain Research Center (ES)
- Hospital Del Mar (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
- Northern California Institute for Research and Education (US)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_099274
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00