Association of Plasma <i>p</i> ‐Tau181 and Cognition in Non‐Demented Individuals: Insights from the BIOCIS Study in Southeast Asia

This study highlights that plasma pTau181 may serve as a minimally invasive biomarker for early cognitive deficits in executive function, processing speed, and visuospatial ability in non-demented individuals with subthreshold amyloid pathology. Longitudinal research is needed to validate these findings and explore its predictive value for progression to AD and integration into early intervention strategies.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_099201
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Association of Plasma p ‐Tau181 and Cognition in Non‐Demented Individuals: Insights from the BIOCIS Study in Southeast Asia

Nagaendran Kandiah, Timothy Aw Bang Hao, Yi Jin Leow
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Association of Plasma p ‐Tau181 and Cognition in Non‐Demented Individuals: Insights from the BIOCIS Study in Southeast Asia

Nagaendran Kandiah, Timothy Aw Bang Hao, Yi Jin Leow
article en

Abstract

This study highlights that plasma pTau181 may serve as a minimally invasive biomarker for early cognitive deficits in executive function, processing speed, and visuospatial ability in non-demented individuals with subthreshold amyloid pathology. Longitudinal research is needed to validate these findings and explore its predictive value for progression to AD and integration into early intervention strategies.

Alzheimer s & DementiaVol. 21(S2)
National University of Singapore (SG), Nanyang Technological University (SG), Singapore Centre for Environmental Life Sciences Engineering (SG)
Quality Education
Openalex Percentile: Top 33%
Dementia and Cognitive Impairment Research
DOIOpen Access PDFOpenAlex
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