Assessing the effect of PrLD proteins on Tau‐induced neurodegeneration
Ultimately, we identified a number of PrLDs whose knockdown ameliorates tau-induced neurodegeneration, suggesting that they promote toxic tau accumulation. This is supported by colocalization of phosphorylated tau and PrLD proteins. Furthermore, tau protein levels are decreased by modifying PrLD expression, making these PrLD proteins attractive therapeutic targets in the context of AD.
Authors
- Ismael Al‐Ramahi (ORCID: https://orcid.org/0000-0002-1275-1114)
- Dylan Lawrence Timperman
- Adulfo Anaya Amador
- Isabella Aguirre‐Lamus
- Khondker Salim
- Eon Lim
- Cassidy Dang
- Joana Wei
- Isabella Rose Juan
Institutions
- Baylor College of Medicine (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Institute for Neurodegenerative Disorders (US)
- Neurological Research Institute (US)
- Texas Children's Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107652
- Primary Topic
- Prion Diseases and Protein Misfolding
- Type
- article
- Field-Weighted Citation Impact
- 0.00