Rare variant associations with late‐life cognitive performance
These results highlight novel rare variants associated with cognition. GAB1 is an AGORA nominated gene target for potential AD treatment. Decreased expression was found in cholinergic neurons in AD patients and decreased learning and memory in a mouse model of AD. PLA2G4A has increased expression in AD patients that is evident in early stages but is decreased in healthy aging brains. Future work will incorporate other ancestries.
Authors
- Michael Cuccaro
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Vilas Menon (ORCID: https://orcid.org/0000-0002-4096-8601)
- Sarah Biber
- Gary W. Beecham (ORCID: https://orcid.org/0000-0002-7061-6332)
- Karen Crawford (ORCID: https://orcid.org/0000-0002-3294-0828)
- Emily H. Trittschuh (ORCID: https://orcid.org/0000-0003-0557-1542)
- Derek B. Archer (ORCID: https://orcid.org/0000-0001-8638-0785)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Tulsi Patel (ORCID: https://orcid.org/0000-0002-2797-1443)
- Corinne D. Engelman (ORCID: https://orcid.org/0000-0003-4750-5607)
- Christiane Reitz (ORCID: https://orcid.org/0000-0001-8757-7889)
- Pauline Maillard (ORCID: https://orcid.org/0000-0003-3516-6345)
- Jeffery M. M Vance
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Phoebe Scollard
- Annie Lee (ORCID: https://orcid.org/0000-0003-3726-6024)
- Duygu Tosun (ORCID: https://orcid.org/0000-0001-5174-3910)
- Elizabeth C. Mormino (ORCID: https://orcid.org/0000-0002-4542-6537)
- Qiongshi Lu (ORCID: https://orcid.org/0000-0002-4514-0969)
- Alaina Durant
- Lisa Laverne Barnes
- Seo‐Eun Choi (ORCID: https://orcid.org/0000-0002-2163-688X)
- Lindsay AA. Farrer
- Andrew Joel Saykin
- Gerald D. Schellenberg
- Kwangsik Nho
- Alexandra N. Regelson
- Li‐San Wang
- Miguel Arce Rentería
- Walter W. Kukull
- Brian Fulton‐Howard
- Adam Brickman
- Philip L. De Jager
- Amanda Kuzma
- Jennifer J. Manly
- Carlos Cruchaga
- Jason Song
- Anita L. DeStefano
- Sterling C Johnson
- Paul K Crane
- Mohamad Habes
- Alison M. Goate
- Richard Mayeux
- Thomas J. Montine
- Alan E. Renton
- Shubhabrata Mukherjee
- Claudia L Satizabal
- Badri N. Vardarajan
- C. Dirk Keene
- Jason M Fletcher
- Sudha Seshadri
- Arthur W. Toga
- Charles S. DeCarli
- Julie A Schneider
- Eric B Larson
- Jesse Mez
- Shannon L Risacher
- David A. A. Bennett
- Edoardo Marcora
- The Alzheimer's Disease Neuroimaging Initiative (ADNI) and The Alzheimer's Disease Sequencing Project (ADSP)
- Michael L. Lee
Institutions
- Boston University (US)
- University of Southern California (US)
- Rush University Medical Center (US)
- University of Wisconsin–Madison (US)
- University of Miami (US)
- The University of Texas at San Antonio Health Science Center (US)
- University of California, San Francisco (US)
- Vanderbilt University (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- Columbia University Irving Medical Center (US)
- VA Puget Sound Health Care System (US)
- Institute for Neurodegenerative Disorders (US)
- Dr. John T. Macdonald Foundation (US)
- Wisconsin Division of Public Health (US)
- New York Genome Center (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Case Western Reserve University (US)
- Columbia University (US)
- University of Pennsylvania (US)
- University of California, Davis (US)
- Vanderbilt University Medical Center (US)
- Stanford University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105742
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00