Frailty and Cerebrovascular Profiles Are Associated with Early Cognitive and Behavioral Impairment in a Community‐Based Southeast Asian Cohort

Frailty is primarily associated with increased NPS; however, the combination of frailty and CSVD amplifies cognitive and behavioral impairments. Our findings suggest CSVD exacerbates cognitive decline in frail individuals, creating a "double burden" of risk for accelerated deterioration. Early, integrated interventions targeting both frailty and cerebrovascular health are essential to mitigate this compounded risk and slow the trajectory of cognitive deterioration.