Trajectories of plasma biomarker levels and Amyloid Burden in Alzheimer's disease: A Longitudinal ADNI Study

While obesity is mainly associated with lower baseline BBM levels, individuals with obesity tend to exhibit faster accumulation of amyloid burden by PET, as well as higher rates of changes in plasma p-tau217 and %p-tau217, compared to non-obese individuals. The findings of this study not only offer valuable insights for interpreting BBM levels in obese versus non-obese individuals but also provide insights on the effects of obesity on AD pathology over time.