Memory impairment across the atypical AD syndromic spectrum

All atypical AD syndromes demonstrated poor encoding and storage loss, adding to the characterization of memory impairment in atypical "non-amnestic" AD. EOAD participants demonstrated faster storage loss compared to the other variants, potentially reflecting multidomain impairment. While PCA and lvPPA performed comparably on object memory, these groups were differentiated by location memory binding. Understanding the varied presentation of memory deficits in atypical syndromes can help inform accurate diagnosis and cognitive skills training to cope with neurodegenerative decline.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_099054
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
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article

Memory impairment across the atypical AD syndromic spectrum

Deepti Putcha, Yuta Katsumi, Brad C. Dickerson, Kanella Basilion
Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
article

Memory impairment across the atypical AD syndromic spectrum

Deepti Putcha, Yuta Katsumi, Brad C. Dickerson, Kanella Basilion
article en

Abstract

All atypical AD syndromes demonstrated poor encoding and storage loss, adding to the characterization of memory impairment in atypical "non-amnestic" AD. EOAD participants demonstrated faster storage loss compared to the other variants, potentially reflecting multidomain impairment. While PCA and lvPPA performed comparably on object memory, these groups were differentiated by location memory binding. Understanding the varied presentation of memory deficits in atypical syndromes can help inform accurate diagnosis and cognitive skills training to cope with neurodegenerative decline.

Alzheimer s & DementiaVol. 21(S3)
Harvard University (US), Massachusetts General Hospital (US)
Quality Education
Openalex Percentile: Top 33%
Dementia and Cognitive Impairment Research
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