Memory impairment across the atypical AD syndromic spectrum
All atypical AD syndromes demonstrated poor encoding and storage loss, adding to the characterization of memory impairment in atypical "non-amnestic" AD. EOAD participants demonstrated faster storage loss compared to the other variants, potentially reflecting multidomain impairment. While PCA and lvPPA performed comparably on object memory, these groups were differentiated by location memory binding. Understanding the varied presentation of memory deficits in atypical syndromes can help inform accurate diagnosis and cognitive skills training to cope with neurodegenerative decline.
Authors
- Deepti Putcha (ORCID: https://orcid.org/0000-0001-5575-5572)
- Yuta Katsumi (ORCID: https://orcid.org/0000-0003-0413-747X)
- Brad C. Dickerson
- Kanella Basilion
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_099054
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00