YKL‐40 as a Biomarker of Inflammation in Chronic Insomnia: A Potential Pathway to Alzheimer's Disease

Our findings suggest that insomnia severity in individuals diagnosed with insomnia is linked to elevated YKL-40 concentrations, independently of multiple confounders. However, the comorbidity between insomnia and mental disorders may play a key role in the selective vulnerability to AD. Future studies should evaluate the interaction of insomnia severity and mental health symptomatology when predicting AD risk and related processes.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70858_098789
Primary Topic
Sleep and related disorders
Type
article
Field-Weighted Citation Impact
0.00
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article

YKL‐40 as a Biomarker of Inflammation in Chronic Insomnia: A Potential Pathway to Alzheimer's Disease

Caroline d'Aragon, REBECCA ROBILLARD, Alex Désautels, Beatriz Helena Domingos Oliveira et al.
Alzheimer s & Dementia
Sleep and related disorders
article

YKL‐40 as a Biomarker of Inflammation in Chronic Insomnia: A Potential Pathway to Alzheimer's Disease

Caroline d'Aragon, REBECCA ROBILLARD, Alex Désautels, Beatriz Helena Domingos Oliveira, Nadia Gosselin, Mélanie Vendette, Erlan Sanchez, Julie Otis, Julie Carrier, Nicole Lazarovici, Marie‐Josée Quinn, Andrée‐Ann Baril, Rayan Daoudi
article en

Abstract

Our findings suggest that insomnia severity in individuals diagnosed with insomnia is linked to elevated YKL-40 concentrations, independently of multiple confounders. However, the comorbidity between insomnia and mental disorders may play a key role in the selective vulnerability to AD. Future studies should evaluate the interaction of insomnia severity and mental health symptomatology when predicting AD risk and related processes.

Alzheimer s & DementiaVol. 21(S4)
University of Ottawa (CA), Hôpital du Sacré-Cœur de Montréal (CA), McGill University (CA), Université de Montréal (CA)
Good health and well-being
Openalex Percentile: Top 29%
Sleep and related disorders
DOIOpen Access PDFOpenAlex
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YKL‐40 as a Biomarker of Inflammation in Chronic Insomnia: A Potential Pathway to Alzheimer's Disease — Caroline d'Aragon, REBECCA ROBILLARD, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS