Hippocampus and Amygdala Volume and Morphology in Neurodegenerative Disorders with Co‐morbid Epilepsy

We identified hippocampal body and tail atrophy in AD+Epi and right hippocampal head, tail, and amygdalar atrophy in nonAD+Epi demonstrating that mesial temporal morphology may serve as a neuroimaging correlate for epilepsy in ADRD. These lateralized and region-specific patterns highlight the possible role of epilepsy in altering the trajectory of neurodegeneration in ADRD, which warrants further investigation.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_097534
Primary Topic
Epilepsy research and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Hippocampus and Amygdala Volume and Morphology in Neurodegenerative Disorders with Co‐morbid Epilepsy

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Hippocampus and Amygdala Volume and Morphology in Neurodegenerative Disorders with Co‐morbid Epilepsy

Ifrah Zawar, Jaideep Kapur, Mark S. Quigg, Shen ZM Zhu, Carol A Manning, P Thomas ZM Fletchet
article en

Abstract

We identified hippocampal body and tail atrophy in AD+Epi and right hippocampal head, tail, and amygdalar atrophy in nonAD+Epi demonstrating that mesial temporal morphology may serve as a neuroimaging correlate for epilepsy in ADRD. These lateralized and region-specific patterns highlight the possible role of epilepsy in altering the trajectory of neurodegeneration in ADRD, which warrants further investigation.

Alzheimer s & DementiaVol. 21(S3)
University of Virginia (US)
Good health and well-being
Openalex Percentile: Top 33%
Epilepsy research and treatment
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