An alternative source of elevated tau phosphorylation in plasma following renal dysfunction

Our data indicated that adenine recapitulated the CKD pathology over six weeks. Significant age-related differences suggested (i) a delayed resolution of renal functions after the treatment or (ii) a more severe renal dysfunction in the aged mice. Altered p-tau status and neuroinflammation onset in the aged CKD mouse brains underscored a novel kidney-brain axis in CKD among elderly patients. Further investigation will concentrate on the chronic effect of CKD on p-tau and whether circulating p-tau levels could be affected in cerebrospinal fluid and plasma.