Comparison of pTau217 and Tau PET between Down syndrome and neurotypical adults at risk for Alzheimer's disease

Individuals with DS have earlier pTau217 and Tau PET progression following PET A+ compared to neurotypical adults. The early and simultaneous onset of these biomarkers in DS highlight the necessity for early AD interventions in this population. This work, combined with the upcoming DSAD clinical trials will help identify optimal treatment windows for these individuals.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_099359
Primary Topic
Down syndrome and intellectual disability research
Type
article
Field-Weighted Citation Impact
0.00
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article

Comparison of pTau217 and Tau PET between Down syndrome and neurotypical adults at risk for Alzheimer's disease

Matthew Zammit
Alzheimer s & Dementia
Down syndrome and intellectual disability research
article

Comparison of pTau217 and Tau PET between Down syndrome and neurotypical adults at risk for Alzheimer's disease

Matthew Zammit
article en

Abstract

Individuals with DS have earlier pTau217 and Tau PET progression following PET A+ compared to neurotypical adults. The early and simultaneous onset of these biomarkers in DS highlight the necessity for early AD interventions in this population. This work, combined with the upcoming DSAD clinical trials will help identify optimal treatment windows for these individuals.

Alzheimer s & DementiaVol. 21(S2)
University of Wisconsin–Madison (US)
Openalex Percentile: Top 26%
Down syndrome and intellectual disability research
DOIOpen Access PDFOpenAlex
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Comparison of pTau217 and Tau PET between Down syndrome and neurotypical adults at risk for Alzheimer's disease — Matthew Zammit · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS