Whole‐brain functional connectivity predicts regional tau PET and future cognitive decline in preclinical Alzheimer's disease

The functional connectome modestly predicts regional tau PET across the AD spectrum. These predictive edges capture meaningful differences in cognitive trajectories, underscoring the relationship between functional connectomic changes, tau burden, and clinical trajectory. Robust prediction of regional tau that correlate with cognitive trajectories suggest that functional connectivity is valuable for early disease staging. Future studies should investigate whether functional connectivity can be combined with other biomarkers to enhance staging accuracy.