Longitudinal Changes in Plasma GFAP and Their Potential Role in Alzheimer's Disease Progression
Plasma GFAP levels are associated with age, APOE ɛ4 status, and cognitive status, with higher levels in dementia and amyloid-positive individuals. GFAP may better predict cognitive decline in A+ individuals, suggesting a synergy between neuroinflammation and amyloid pathology. Further research is needed to investigate this interaction.
Authors
- Yung‐Shuan Lin (ORCID: https://orcid.org/0000-0003-3170-5516)
- Wei‐Ju Lee (ORCID: https://orcid.org/0000-0003-4326-333X)
- Yu‐Yang Hung
- Jong‐Ling Fuh
Institutions
- Taipei Veterans General Hospital (TW)
- Taichung Veterans General Hospital (TW)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104085
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00