Correlations of amyloid accumulation, brain atrophy and cognitive decline in emergent Alzheimer's disease
During the emergent stage of AD, Aβ accumulation occurs without accompanying accelerated atrophy in the BF and hippocampus. However, the association between Aβ accumulation and episodic memory loss indicates that Aβ-related neuronal dysfunction may begin prior to detectable volumetric changes.
Authors
- Vincent Doré (ORCID: https://orcid.org/0000-0002-8051-0558)
- Yen Ying Lim (ORCID: https://orcid.org/0000-0002-0308-5156)
- Paul T. Maruff (ORCID: https://orcid.org/0000-0002-6947-9537)
- C. Rowe
- Colin L. Masters
- Elizabeth J Coulson
- Pierrick Bourgeat
- Christopher J Fowler
- Ying Xia
- Simon M. Laws
- for the AIBL study investigators
- Jurgen Fripp
Institutions
- Edith Cowan University (AU)
- The University of Queensland (AU)
- The University of Melbourne (AU)
- Curtin University (AU)
- Florey Institute of Neuroscience and Mental Health (AU)
- Australian e-Health Research Centre (AU)
- CSIRO Health and Biosecurity (AU)
- Austin Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100789
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00