Generation of Isogenic Induced Pluripotent Stem Cell Lines Derived From Individuals Mosaic for Loss of the Y Chromosome
We have generated paired iPSC cell lines derived from AD and cognitively normal individuals that allow for explicit examination of the impact of LOY on AD-relevant cell types.
Authors
- Eugene Tang (ORCID: https://orcid.org/0000-0001-5192-2521)
- Tianjie Gu
- Derek M. Dykxhoorn (ORCID: https://orcid.org/0000-0002-4998-9943)
- Holly N. Cukier (ORCID: https://orcid.org/0000-0003-3459-7792)
- Brooke A. DeRosa (ORCID: https://orcid.org/0000-0002-7878-9799)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Yeunjoo E. Song (ORCID: https://orcid.org/0000-0002-7452-3731)
- Anthony J. Griswold (ORCID: https://orcid.org/0000-0003-1925-7810)
- Lauren Coombs
- Margaret Pericak‐Vance
- Jonathan L Haines
Institutions
- University of Miami (US)
- Dr. John T. Macdonald Foundation (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106554
- Primary Topic
- Pluripotent Stem Cells Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00