Global and Regional White Matter Hyperintensities in Alzheimer's Disease: Exploring Etiologies and Cognitive Correlates
In AD patients, WMH-particularly in the frontal, parietal, and paraventricular regions-are associated with AD-related pathology, including CSF Aβ42 levels and CMB, but not with CSF tau levels or vascular risk factors. Notably, paraventricular WMH are significantly linked to cognitive decline, independent of cortical atrophy.
Authors
- Li Shang (ORCID: https://orcid.org/0009-0006-4062-1065)
- Yuyue Qiu (ORCID: https://orcid.org/0000-0002-9712-2404)
- DongJing Li
- Y Li
- Jialu Bao (ORCID: https://orcid.org/0000-0001-9407-3339)
- Wenjun Wang (ORCID: https://orcid.org/0000-0003-2890-6878)
- Ying Huang (ORCID: https://orcid.org/0000-0002-4627-1661)
- Yuhan Jiang (ORCID: https://orcid.org/0009-0001-1098-0722)
- Qi Xu (ORCID: https://orcid.org/0000-0001-9437-3956)
- Ling Qiu
- longze sha
- Yunfan You
- Shanshan Chu
- Chenhui Mao
- Liling Dong
- Bo Hou
- Bo Li
- Jing Gao
- Wei Jin
- Tianyi Wang
- Feng Feng
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_102956
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00