Efficacy and safety of anti-VEGF monoclonal antibody 601 for macular oedema in retinal vein occlusion: two phase IIa randomised clinical trials

These trials demonstrate that 601 is as effective and safe as ranibizumab for improving vision and reducing CST in RVO-related macular oedema. Phase III trials are warranted.

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Publication Details

Journal
British Journal of Ophthalmology
Published
2025-12-25
DOI
https://doi.org/10.1136/bjo-2025-327845
Primary Topic
Retinal Diseases and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Efficacy and safety of anti-VEGF monoclonal antibody 601 for macular oedema in retinal vein occlusion: two phase IIa randomised clinical trials

Jingxiang Zhong, Fang Wang, Suqin Yu, H. Wang et al.
British Journal of Ophthalmology
Retinal Diseases and Treatments
article

Efficacy and safety of anti-VEGF monoclonal antibody 601 for macular oedema in retinal vein occlusion: two phase IIa randomised clinical trials

Jingxiang Zhong, Fang Wang, Suqin Yu, H. Wang, Mingwei Zhao, Yanli Liu, Mengqi Wu, Quanhong Han, Baihua Chen, X. Y. Li, Shuo Zhao, Songtao Yuan, Zhang Ming, Qinghong Zhou, Xiaohong Meng, Hong Dai, Zongming Song, Haomin Huang, Yuyu Xu, Jin Yao, Jing Lou
article en

Abstract

These trials demonstrate that 601 is as effective and safe as ranibizumab for improving vision and reducing CST in RVO-related macular oedema. Phase III trials are warranted.

British Journal of Ophthalmology
Southwest General Health Center (US), Central South University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking University (CN), Sichuan University (CN), West China Hospital of Sichuan University (CN), Shanghai Eye Disease Prevention & Treatment Center (CN), Peking University People's Hospital (CN), Southwest Hospital (CN), Second Affiliated Hospital of Xi'an Jiaotong University (CN), Henan Provincial People's Hospital (CN), Tianjin Medical University Eye Hospital (CN), Shanghai Sunshine Rehabilitation Center (CN), Jiangsu Province Hospital (CN), Second Xiangya Hospital of Central South University (CN), Henan Provincial Eye Hospital (CN), Shanghai Clinical Research Center (CN), First Affiliated Hospital of Jinan University (CN), Hangzhou Medical College (CN), Tianjin Medical University (CN), Nanjing Medical University (CN)
Good health and well-being
Openalex Percentile: Top 29%
Retinal Diseases and Treatments
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