Distinct awareness trajectories and plasma <i>p</i> ‐tau217 accumulation over time in preclinical Alzheimer's disease
The decreased ACF trajectory strongly aligned with AD pathology, highlighting its role as a potential marker of the disease. The integration of a non-invasive plasma biomarker with awareness represents a groundbreaking approach, providing novel insights into the earliest changes of awareness in AD. This combined clinical-biological strategy could pave the way for earlier detection strategies and improved understanding of preclinical disease dynamics.
Authors
- Ibai Díez (ORCID: https://orcid.org/0000-0001-5769-0178)
- Patrizia Vannini (ORCID: https://orcid.org/0000-0002-9425-1059)
- David López‐Martos (ORCID: https://orcid.org/0009-0008-1150-2619)
- Gonzalo Sánchez‐Benavides
- Oriol Grau‐Rivera
Institutions
- Ikerbasque (ES)
- Harvard University (US)
- Gordon Center for Medical Imaging (US)
- Massachusetts General Hospital (US)
- BioCruces Health research Institute (ES)
- Pasqual Maragall Foundation (ES)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Barcelonaβeta Brain Research Center (ES)
- Hospital Del Mar (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_101104
- Primary Topic
- Spatial Neglect and Hemispheric Dysfunction
- Type
- article
- Field-Weighted Citation Impact
- 0.00