Molecular and Immune Microenvironmental Changes Across Endometrial Lesions: A Comprehensive Immunohistochemical and Clinical Analysis of Progression From Benignity to Carcinoma

The stepwise evolution from benign endometrial lesions to carcinoma is driven by coordinated proliferative and immune microenvironmental shifts, potentiated by a history of atypical endometrial hyperplasia. Integrating immunohistochemical and clinical risk factors may enhance early identification and surveillance of patients at high risk for endometriosis-associated carcinoma.