Exploring the Cross‐sectional Association of Mood Symptoms with Subjective and Objective Cognition in the A4 study

Depressive symptoms are strongly associated with both subjective and objective cognitive measures, independent of tau and amyloid pathology, highlighting the importance of addressing mood symptoms in individuals at risk for AD. Anxiety symptoms, in contrast, appear to have minimal influence on cognition in this cohort. These findings underscore the value of incorporating assessments of mood symptoms into AD research to refine early detection strategies and intervention approaches.