Dose-Dependent Effects of Radiation on the Coronary Arteries: Results From a Preclinical Model of Single-Fraction Proton Beam Cardiac Radioablation
In this preclinical model of proton beam cardiac radioablation, coronary stenoses occurred in a dose-dependent manner, with D<sub>max</sub> showing the closest correlation with stenosis ≥75%. These data provide for the first time a framework for dose constraint considerations for the coronary arteries during treatment planning for cardiac radioablation and thoracic malignancy radiation.
Authors
- Taro Koya (ORCID: https://orcid.org/0000-0003-2154-4587)
- Jon J. Kruse (ORCID: https://orcid.org/0000-0002-6177-2077)
- Tatsuhiko Hirao (ORCID: https://orcid.org/0000-0003-2014-8726)
- Dean A. Shumway (ORCID: https://orcid.org/0000-0001-7758-8891)
- Laura K. Newman (ORCID: https://orcid.org/0000-0001-7588-948X)
- Maryam E. Rettmann (ORCID: https://orcid.org/0000-0002-7581-3570)
- Naomi M. Gades (ORCID: https://orcid.org/0000-0003-2581-2243)
- A. Deisher
- Amir Lerman
- Konstantinos C. Siontis
- Kenneth W. Merrell
- Samuel J. Asirvatham
- Douglas L. Packer
Institutions
- Mayo Clinic (US)
- Intermountain Medical Center (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Circulation Arrhythmia and Electrophysiology
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1161/circep.125.013995
- Primary Topic
- Cardiac Arrhythmias and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00