Preliminary Developmental Safety Assessment of Allylestrenol in Pregnant SD Rats: Evaluation of F0 and Early F1 Generational Endpoints
Allylestrenol at doses of 5, 10, and 20 mg kg<sup>-1</sup> did not result in overt developmental abnormalities in maternal or offspring rats across selected early endpoints. However, further long-term and functional evaluations across generations are needed to fully establish its safety profile.
Authors
- Dajin Li (ORCID: https://orcid.org/0000-0002-9653-428X)
- He Wen
- Lai Jiang
- Wenjie Jin
- Shengnan Zhuan
Institutions
- University of Science and Technology of China (CN)
- Shanghai Medical College of Fudan University (CN)
- Bengbu Medical College (CN)
- Tianjin Tianhe Hospital (CN)
- Obstetrics and Gynecology Hospital of Fudan University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/dddt.s529390
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 0.00