HELZ2 Regulates <i>Apob</i> mRNA Stability to Modulate Fatty Liver Disease and Atherosclerosis
HELZ2 is a key regulator of <i>Apob</i> mRNA stability and lipid metabolism. Genetic or pharmacological modulation of HELZ2 activity represents a promising therapeutic strategy for cardiovascular disease and metabolic dysfunction-associated steatotic liver disease.
Authors
- Yiao Jiang (ORCID: https://orcid.org/0000-0001-8236-4868)
- Z. Zhang
Institutions
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1161/circulationaha.125.076468
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 0.00