Retinal Ganglion Cell Degeneration Linked to Pathogenic Tau Accumulation in Early and Late Stages of Alzheimer's Disease
Our findings suggest that abnormal tau-isoforms accumulate within RBPMS<sup>+</sup> RGCs in MCI and AD patients, contributing to early and pronounced RGC loss and correlating with disease severity. This link involves apoptotic and GVD-necroptotic cell death pathways. Future research should validate these results in larger cohorts and develop RGC-tauopathy as a noninvasive biomarker for early AD detection and monitoring.
Authors
- Rakez Kayed
- Altan Rentsendorj (ORCID: https://orcid.org/0009-0001-4322-8107)
- Elena Salobrar‐García (ORCID: https://orcid.org/0000-0001-5939-5551)
- Dieu‐Trang Fuchs
- Maya Koronyo‐Hamaoui (ORCID: https://orcid.org/0000-0003-2864-8442)
- Edward K. Robinson
- Miyah R. Davis
- L. S. Schneider
- Bhakta Prasad Gaire
- Keith L Black
- Alfredo A Sadun
- Yosef Koronyo
Institutions
- University of Southern California (US)
- Universidad Complutense de Madrid (ES)
- Cedars-Sinai Medical Center (US)
- University of California, Los Angeles (US)
- Doheny Eye Institute (US)
- The University of Texas Medical Branch at Galveston (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100353
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00