Dye Free Polarized Light Differentiation of Protein Deposits in Post‐mortem Retinas of Individuals with FTLD and ALS compared to those with Alzheimer's Disease

Significant differences in many polarized light interactions are consistent with the known physical properties of the different brain (and retinal) amyloid and non-amyloid deposits. Combinations of these interactions are expected to give early, non-invasive, less expensive, differential diagnoses of neurodegenerative brain diseases, including those associated with amyloid beta, alpha-synuclein and TDP-43.