Olfactory dysfunction relates to lower glymphatic functioning as measured by DTI‐ALPS in cognitively unimpaired individuals with family history of dementia
CU individuals with low performance on a short olfactory identification test exhibit reduced glymphatic function as measured by DTI-ALPS. This association was observed even in the normal olfactory range. Further longitudinal studies are needed to validate OD as a potential clinical marker of glymphatic dysfunction in individuals at risk of cognitive impairment.
Authors
- Anna Brugulat‐Serrat (ORCID: https://orcid.org/0000-0001-8988-5658)
- Gemma Salvadó (ORCID: https://orcid.org/0000-0002-5210-9230)
- Juan Domingo Gispert (ORCID: https://orcid.org/0000-0002-6155-0642)
- Michalis Kassinopoulos (ORCID: https://orcid.org/0000-0003-4312-4401)
- Natàlia Vilor‐Tejedor (ORCID: https://orcid.org/0000-0003-4935-6721)
- David López‐Martos (ORCID: https://orcid.org/0009-0008-1150-2619)
- Gonzalo Sánchez‐Benavides
- Oriol Grau‐Rivera
- David Valléz García
- Mariateresa Buongiorno
Institutions
- Radboud University Nijmegen (NL)
- Lund University (SE)
- Instituto de Salud Carlos III (ES)
- Radboud University Medical Center (NL)
- Pasqual Maragall Foundation (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Barcelonaβeta Brain Research Center (ES)
- Hospital Del Mar (ES)
- Centre for Genomic Regulation (ES)
- AstraZeneca (Spain) (ES)
- Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_102197
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00