Tracking longitudinal brain atrophy in dementia and cognitive impairment: insights from the Framingham Heart Study
This study identified atrophy developing MRI features (52 MCI and 143 dementia) from different brain regions with clinical diagnosis, cognitive decline, and plasma AD biomarkers. Our findings suggest that these brain regions will be important in better understanding dementia heterogeneity, particularly as clinical phases or distinct biological subtypes.
Authors
- Xiaoling Zhang (ORCID: https://orcid.org/0000-0001-8237-1857)
- Rhoda Au (ORCID: https://orcid.org/0000-0001-7742-4491)
- Ting Fang Alvin Ang (ORCID: https://orcid.org/0000-0003-4687-2552)
- Douglas N. Greve (ORCID: https://orcid.org/0000-0002-0610-0155)
- Habbiburr Rehman (ORCID: https://orcid.org/0000-0003-1762-3573)
- Lindsay AA. Farrer
- Jesse Mez
- Qiushan Tao
- Wei Qiao Qiu
Institutions
- Boston University (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Framingham Heart Study (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107409
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00