Change in functional connectivity strength during rest and encoding is differentially related to Alzheimer's pathology and memory depending on <i>APOE</i> genotype
Our study shows APOE-dependent and region-specific associations of ΔFC strength within and between episodic memory areas with pathology burden and memory performance. Notably, associations differed between RSFC and task-FC. In APOE4 carriers, longitudinally increasing FC or "hyperconnectivity" within MTL during encoding was related to tau in line with our hypothesis. However, in PMC, longitudinally decreasing FC during rest was related to more amyloid, indicating a disconnection in PMC regions. Our study highlights that pathology-related network changes manifest differentially during rest and task (memory encoding).
Authors
- Jennifer Tremblay‐Mercier (ORCID: https://orcid.org/0000-0001-5824-3740)
- Jordana Remz
- Larissa Fischer (ORCID: https://orcid.org/0009-0001-9936-2954)
- Jenna N. Adams (ORCID: https://orcid.org/0000-0002-6702-3851)
- Natasha Rajah
- Sylvia Villeneuve (ORCID: https://orcid.org/0000-0003-2338-0467)
- Eóin N. Molloy (ORCID: https://orcid.org/0000-0002-7804-2214)
- Anne Maass
- Alexa Pichet Binette
Institutions
- Malmö University (SE)
- University of California, Irvine (US)
- Douglas Mental Health University Institute (CA)
- German Center for Neurodegenerative Diseases (DE)
- Metropolitan University (RS)
- Institut Universitaire de Gériatrie de Montréal (CA)
- McGill University (CA)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100192
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00