Diagnostic blind spot in clinical manifestations: anosognosia trajectory in preclinical Alzheimer's is linked to core pathophysiology, astrocytic reactivity, and structural changes in cognitive control and self‐referential brain regions

These results demonstrated that anosognosia's trajectory is linked to AD pathophysiology and structural brain changes in pre-MCI stages, underscoring the need for early detection methods beyond self-reported symptoms. Identifying high-risk individuals who may delay or not seek medical attention is critical for implementing objective diagnostics and prevention, still current criteria fail to explicitly address this challenge.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_101106
Primary Topic
Spatial Neglect and Hemispheric Dysfunction
Type
article
Field-Weighted Citation Impact
0.00
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article

Diagnostic blind spot in clinical manifestations: anosognosia trajectory in preclinical Alzheimer's is linked to core pathophysiology, astrocytic reactivity, and structural changes in cognitive control and self‐referential brain regions

Armand González Escalante, Raffaele Cacciaglia, Gwendlyn Kollmorgen, Kaj Blennow et al.
Alzheimer s & Dementia
Spatial Neglect and Hemispheric Dysfunction
article

Diagnostic blind spot in clinical manifestations: anosognosia trajectory in preclinical Alzheimer's is linked to core pathophysiology, astrocytic reactivity, and structural changes in cognitive control and self‐referential brain regions

Armand González Escalante, Raffaele Cacciaglia, Gwendlyn Kollmorgen, Kaj Blennow, Carolina Minguillón, David López‐Martos, Clara Quijano‐Rubio, Alfa Study, Gonzalo Sánchez‐Benavides, Oriol Grau‐Rivera, Marta Milà‐Alomà, Juan Domingo Gispert, Marc Suárez‐Calvet, Henrik Zetterberg
article en

Abstract

These results demonstrated that anosognosia's trajectory is linked to AD pathophysiology and structural brain changes in pre-MCI stages, underscoring the need for early detection methods beyond self-reported symptoms. Identifying high-risk individuals who may delay or not seek medical attention is critical for implementing objective diagnostics and prevention, still current criteria fail to explicitly address this challenge.

Alzheimer s & DementiaVol. 21(S3)
Roche (Switzerland) (CH), University of Wisconsin–Madison (US), Universitat Pompeu Fabra (ES), University of California, San Francisco (US), Hong Kong Science and Technology Parks Corporation (HK), Sahlgrenska University Hospital (SE), Roche Pharma AG (Germany) (DE), Pasqual Maragall Foundation (ES), UK Dementia Research Institute (GB), Barcelonaβeta Brain Research Center (ES), Hospital Del Mar (ES), Wisconsin Division of Public Health (US), AstraZeneca (Spain) (ES), Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (ES), National Hospital for Neurology and Neurosurgery (GB), Northern California Institute for Research and Education (US), University College London (GB), University of Gothenburg (SE)
Openalex Percentile: Top 32%
Spatial Neglect and Hemispheric Dysfunction
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