Genetic Intersections of ADHD and Alzheimer's Disease: A Systematic Review

This review identifies genetic and molecular overlaps between ADHD and AD, emphasizing the potential for early identification of at-risk populations through PRS. Future research should prioritize longitudinal studies and interventions targeting shared pathways to mitigate neurodevelopmental and neurodegenerative risks. Bibliography Garcia-Argibay, M., du-Rietz, E., Lu, Y., Martin, J., Haan, E., Lehto, K., Bergen, S.E., Lichtenstein, P., Larsson, H., & Brikell, I. (2022). The role of ADHD genetic risk in mid-to-late life somatic health conditions. Translational Psychiatry, 12(1), 152. https://doi.org/10.1038/s41398-022-01919-9. Leffa, D.T., Gilsanz, A.H., Solomon, I.H., Salinas, J., Laibson, M.J., & Bandeen-Roche, K.A. (2023). ADHD polygenic risk scores influence Alzheimer's disease pathology: A longitudinal biomarker study. Neurobiology of Aging. https://doi.org/10.1016/j.neurobiolaging.2023.03.015.