Estradiol and hormone therapy: Associations with cognitive and behavioural changes in postmenopausal females
Higher estradiol levels and HT-use were independently associated with lower MBI symptom severity but not better MoCA scores, suggesting neuropsychiatric markers such as MBI may be more sensitive to postmenopausal estradiol changes than cognitive assessments. However, longitudinal biomarker studies are needed to elucidate underlying mechanisms.
Authors
- Eric Edward Smith (ORCID: https://orcid.org/0000-0003-3956-1668)
- Dylan X. Guan (ORCID: https://orcid.org/0000-0002-7065-1963)
- Maryam Ghahremani (ORCID: https://orcid.org/0000-0001-8063-713X)
- Cindy K. Barha (ORCID: https://orcid.org/0000-0003-3149-5539)
- Gillian Einstein (ORCID: https://orcid.org/0000-0002-0770-5471)
- Zahinoor Ismail
- Jasper F.E.U. Crockford
Institutions
- University of Calgary (CA)
- University of Toronto (CA)
- Baycrest Hospital (CA)
- Ontario Brain Institute (CA)
- Hotchkiss Brain Institute (CA)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_102190
- Primary Topic
- Menopause: Health Impacts and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00