CSF synaptic markers are associated with cognitive resilience in aging and preclinical Alzheimer's disease
Baseline levels of synaptic proteins NPTX2 and VGF were associated with reduced rates of cognitive decline, independent of AD biomarker levels. The results are consistent with the hypothesis that these markers may impart resilience to cognitive decline in the presence of AD pathology and may hold promise as potential therapeutic targets for AD.
Authors
- Anja Soldan (ORCID: https://orcid.org/0000-0002-6193-0418)
- Alden L. Gross (ORCID: https://orcid.org/0000-0002-4678-0562)
- Corinne Pettigrew
- Chan Hyun Na (ORCID: https://orcid.org/0000-0002-3622-2938)
- Juan P. Vazquez (ORCID: https://orcid.org/0000-0001-8930-8009)
- Hang Wang (ORCID: https://orcid.org/0000-0002-6347-8568)
- Marilyn S. S. Albert
- Abhay Moghekar
- Sungtaek Oh
- Claire L Anderson
- Paul F Worley
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103160
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00